Hashimoto K, Toi Y, Horton S, Sun T T
Department of Dermatology & Syphilology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
J Cutan Pathol. 1999 Jan;26(1):25-30. doi: 10.1111/j.1600-0560.1999.tb01786.x.
Six cases of spiny keratoderma were analyzed with hair specific antikeratin antibodies (AE13, AE14) and by electron microscopy. The keratotic column exhibited a different keratin birefringence and the underlying viable epidermis was less eosinophilic than the surrounding epidermis. AE13, which is specific for hair cortex, was positive in the lower column and variably positive in the viable epidermis, often beyond the columnar lesion. AE14 was negative in the lesion. Electron microscopy demonstrated features of keratinization of normal hair cortex, i.e. by the accretion of keratin filaments without production of keratohyalin or trichohyalin granules. Cementsomes (lamellar granules) and marginal bands were not produced as they are not formed in normal cortical keratinization. It was suggested that spiny keratoderma represents an ectopic hair formation of palms and soles.
运用毛发特异性抗角蛋白抗体（AE13、AE14）并通过电子显微镜对6例棘状角化病进行了分析。角化柱呈现出不同的角蛋白双折射现象，其下方的活表皮嗜酸性比周围表皮弱。对毛皮质具有特异性的AE13在角化柱下部呈阳性，在活表皮中呈不同程度阳性，通常超出柱状病变范围。AE14在病变中呈阴性。电子显微镜显示出正常毛皮质的角化特征，即通过角蛋白丝的积聚而不产生透明角质颗粒或毛透明颗粒。未产生板层颗粒（板层小体）和边缘带，因为它们在正常皮质角化过程中不形成。提示棘状角化病代表手掌和足底的异位毛发形成。
