Pukhalskaya Tatsiana, Mully Thaddeus W, Wei Maria L
Department of Pathology, Dermatopathology and Oral Pathology Services, University of California San Francisco, San Francisco, CA 94115, USA.
Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA.
Dermatopathology (Basel). 2023 May 22;10(2):142-146. doi: 10.3390/dermatopathology10020021.
Spiny keratoderma (SK) was first described by Brown in 1871 and is characterized by numerous 1-2 mm spines of keratin on the palms and soles, usually sparing the dorsal surfaces, or disseminated over the trunk. Histologically, the "spine" represents a column of hyperkeratosis. Several different forms are known, including familial, sporadic, post-inflammatory and paraneoplastic. Although an association of SK with melanoma has been reported, the significance of such co-occurrence remains unclear due to the limited number of cases. To increase the body of knowledge and shed further light on this rare condition, we present a case of SK in a patient with a recent history of melanoma in situ.
棘状角化病（SK）于1871年由布朗首次描述，其特征是手掌和脚底有许多1 - 2毫米的角质棘，通常不累及背面，或散布于躯干。组织学上，“棘”代表角化过度柱。已知有几种不同形式，包括家族性、散发性、炎症后性和副肿瘤性。虽然有报道称SK与黑色素瘤有关联，但由于病例数量有限，这种共现的意义仍不清楚。为了增加知识储备并进一步阐明这种罕见病症，我们报告一例近期有原位黑色素瘤病史患者的SK病例。
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