Borneo Marine Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia.
Biotechnology Research Institute, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia.
Molecules. 2022 Feb 24;27(5):1533. doi: 10.3390/molecules27051533.
Hepatotoxicity is a major global public health concern. Despite advances in modern medicine, the demerits of chemically prepared drugs outweigh their merits. In addition, the treatment of liver diseases based on modern medical principles has been found to produce several undesired side effects. Therefore, the exploration of medicinal plants has gained worldwide attention for treating various diseases, including liver diseases, owing to their potential efficacy and cost effectiveness. Several plants, including , , , , , , and , have been reported with hepatoprotection. Moreover, these plants have been shown to play a vital role in ameliorating cellular damage because they contain several phytochemicals, including alkaloids, saponins, flavonoids, tannins, terpenoids, steroids, polyphenols, and diterpenoid lactones. The following antioxidant, anti-inflammatory, immunomodulatory, and hepatoprotective compounds have been found in these plants: andrographolide, rosmarinic acid, phenol, eugenol, 9,12-octadecadienoic, n-hexadecanoic acid, dihydroxy dimethoxy flavone, sitosterol, demethoxycurcumin, quercetin, linoleic acid, stigmasterol, kojic acid, indole-2-one, α-terpinol, linalool, kaempferol, catechin, ellagic acid, and oleanolic acid. This paper aimed to provide an in-depth review of in vivo studies on Malaysian medicinal plants possessing hepatoprotective properties, phytochemical ingredients, and antioxidant mechanisms, with an emphasis on the species proven particularly useful for treating hepatic disorders.
肝毒性是一个全球性的主要公共卫生关注点。尽管现代医学取得了进步，但化学制备药物的缺点超过了其优点。此外，基于现代医学原理治疗肝脏疾病已被发现会产生一些不良的副作用。因此，药用植物的探索因其潜在的疗效和成本效益而受到全球关注，可用于治疗各种疾病，包括肝脏疾病。有报道称， 、 、 、 、 、 等几种植物具有保肝作用。此外，这些植物在改善细胞损伤方面发挥着重要作用，因为它们含有几种植物化学物质，包括生物碱、皂甙、类黄酮、单宁、萜类、甾体、多酚和二萜内酯。这些植物中发现了以下具有抗氧化、抗炎、免疫调节和保肝作用的化合物：穿心莲内酯、迷迭香酸、苯酚、丁香酚、9,12-十八碳二烯酸、正十六烷酸、二羟基二甲氧基黄酮、豆甾醇、去甲氧基姜黄素、槲皮素、亚油酸、豆甾醇、曲酸、吲哚-2-酮、α-松油醇、芳樟醇、山奈酚、儿茶素、鞣花酸和齐墩果酸。本文旨在深入综述具有保肝特性、植物化学成分和抗氧化机制的马来西亚药用植物的体内研究，重点介绍对治疗肝脏疾病特别有用的物种。
