Lemus I, García R, Delvillar E, Knop G
Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile.
Phytother Res. 1999 Mar;13(2):91-4. doi: 10.1002/(SICI)1099-1573(199903)13:2<91::AID-PTR350>3.0.CO;2-8.
The hypoglycaemic activity of a 20% dried leaf infusion of Bauhinia candicans Benth. (Leguminosae), Galega officinalis L. (Leguminosae), Morus alba L. (Moraceae) and Rubus ulmifolius Schott. (Rosaceae), used for diabetes in Chilean popular medicine, was evaluated in alloxan and streptozotocin induced hyperglycaemic rats. In normal rats the different infusions did not modify significantly the glycaemia in the period studied, but in diabetic rats different results were observed, depending on the diabetogenic drug used. B. candicans and R. ulmifolius infusions elicited remarkable hypoglycaemic effects in both experimental models. B. candicans presented a greater decrease of glycaemia in alloxan diabetic rats (39%) and R. ulmifolius showed a similar activity in both alloxan and streptozotocin diabetic rats (28% and 29%). Activity-guided fractionation of R. ulmifolius showed that petroleum ether extracts elicited a marked hypoglycaemic effect (35%) in the streptozotocin induced model.
智利传统医学中用于治疗糖尿病的羊蹄甲（豆科）、山羊豆（豆科）、白桑（桑科）和榆叶悬钩子（蔷薇科）20%干叶浸剂的降血糖活性，在四氧嘧啶和链脲佐菌素诱导的高血糖大鼠中进行了评估。在正常大鼠中，在所研究的时间段内，不同的浸剂对血糖没有显著影响，但在糖尿病大鼠中，根据所用的致糖尿病药物不同，观察到了不同的结果。羊蹄甲和榆叶悬钩子浸剂在两种实验模型中均产生了显著的降血糖作用。羊蹄甲在四氧嘧啶糖尿病大鼠中血糖降低幅度更大（39%），榆叶悬钩子在四氧嘧啶和链脲佐菌素糖尿病大鼠中均表现出类似的活性（28%和29%）。榆叶悬钩子的活性导向分级分离表明，石油醚提取物在链脲佐菌素诱导的模型中产生了显著的降血糖作用（35%）。
