Seaton B A, Dedman J R
Department of Physiology, Boston University School of Medicine, MA 02118, USA.
Biometals. 1998 Dec;11(4):399-404. doi: 10.1023/a:1009205925714.
The annexins are a family of proteins that bind anionic phospholipid surfaces in a Ca(2+)-dependent manner (general reviews include Raynal & Pollard 1994, Swairjo & Seaton 1994, Seaton 1996, Mollenhauer, 1997). Due to this functional property, individual annexins have been discovered independently by numerous laboratories with diverse experimental goals. Ca2+ characteristically causes the annexins to shift from a soluble to membrane associated state. This shift is believed to be the mechanism that underlies annexin cellular function.
膜联蛋白是一类能以Ca(2+)依赖方式结合阴离子磷脂表面的蛋白质家族（综述文章包括Raynal和Pollard，1994；Swairjo和Seaton，1994；Seaton，1996；Mollenhauer，1997）。由于这一功能特性，众多实验室基于不同的实验目的独立发现了各个膜联蛋白。Ca2+的典型作用是使膜联蛋白从可溶状态转变为与膜结合的状态。这种转变被认为是膜联蛋白细胞功能的潜在机制。
