Jülich W D, Ohme R, Alhitari N, Adrian V, von Woedtke T, Kramer A
Landeshygieneinstitut Mecklenburg-Vorpommern, Greifswald, Germany.
Pharmazie. 1999 Mar;54(3):171-8.
A substantial extension of the applicability of hydrogen peroxide will be reached by using occlusion compounds of anionic, amphoteric (dipolar ionic), cationic, nonionic, or polyfunctional tensides with hydrogen peroxide in urea. Occlusion compounds with 3 as well as with 4 components containing natural equivalent and antimicrobial effective tensides were synthesized and tested. By synthesis in an anhydrous system the content of active substances as well as the mixture ratio of the components may be adapted to the conditions necessary according to the appropriate purpose. Occlusion compounds are characterized by a broad and well-balanced spectrum of antimicrobial effectivity. Concentrations in the range of 0.1 to 0.4% are practicable to preserve pharmaceutical preparations or technical products, respectively. Several compounds show a sporicidal activity in concentrations between 0.3 and 0.6% and, with an appropriate action time (> 24 h) also a moderate effectivity against polioviruses. In the conventional cell culture, in the perfusion cell culture, and in the phytotoxicity test using cress seed, respectively, low biological activity of the occlusion compounds was found.
通过使用阴离子、两性（偶极离子）、阳离子、非离子或多官能表面活性剂与过氧化氢在尿素中的包合化合物，将实现过氧化氢适用性的大幅扩展。合成并测试了含有天然等效和抗菌有效表面活性剂的三元以及四元包合化合物。通过在无水体系中合成，活性物质的含量以及各组分的混合比例可根据适当目的适应所需条件。包合化合物的特点是具有广泛且平衡良好的抗菌效果谱。浓度在0.1%至0.4%的范围内分别适用于保存药物制剂或工业产品。几种化合物在0.3%至0.6%的浓度下具有杀孢子活性，并且在适当的作用时间（>24小时）下对脊髓灰质炎病毒也有一定的效果。分别在常规细胞培养、灌注细胞培养以及使用水芹种子的植物毒性试验中，发现包合化合物的生物活性较低。
