Fenn A J, Wolf G L, Fogle R M
Lincoln Laboratory, Massachusetts Institute of Technology, Lexington 02420-9108, USA.
Int J Hyperthermia. 1999 Jan-Feb;15(1):45-61. doi: 10.1080/026567399285846.
It has previously been reported in phantoms, that an adaptive radiofrequency phased array can generate deep focused heating distributions without overheating the skin and superficial healthy tissues. The present study involves adaptive microwave phased array hyperthermia tests in animals (rabbits) with and without tumours. The design of the adaptive phased array as applied to the treatment of tumours in intact breast, is described. The adaptive phased array concept uses breast compression and dual-opposing 915 MHz air-cooled waveguide applicators with electronic phase shifters and electric-field feedback, to focus automatically by computer control the microwave radiation in deep tissue. Temperature measurements for a clinical adaptive phased array hyperthermia system demonstrate tissue heating at depth with reduced skin heating.
此前在模型中已有报道，自适应射频相控阵可产生深部聚焦热分布，而不会使皮肤和浅表健康组织过热。本研究涉及在有肿瘤和无肿瘤的动物（兔子）身上进行自适应微波相控阵热疗试验。描述了应用于完整乳房肿瘤治疗的自适应相控阵设计。自适应相控阵概念采用乳房压迫和带有电子移相器及电场反馈的双对置915MHz风冷波导辐射器，通过计算机控制自动将微波辐射聚焦于深部组织。临床自适应相控阵热疗系统的温度测量结果表明，深部组织有加热，而皮肤加热减少。
