Wiesli P, Bernauer W, Furrer J
Department of Internal Medicine, Medical Policlinic, University Hospital of Zürich, Switzerland.
J Endocrinol Invest. 1999 Feb;22(2):141-3. doi: 10.1007/BF03350894.
We describe the exceptional association of Vogt-Koyanagi-Harada syndrome (VKHS) and hypothyroidism in a 29-year-old man of Indian heritage. VKHS is a rare uveomeningoencephalitic syndrome with probably autoimmune pathogenesis. Nontraumatic uveitis, aseptic meningoencephalitis, vitiligo, alopecia and poliosis are the leading clinical features of VKHS. The reported patient presented with bilateral visual loss and progressive frontal headache. VKHS was diagnosed due to characteristic ophthalmological findings and the diagnosis of aseptic meningitis. Due to the autoimmune pathogenesis, VKHS may be rarely associated with other autoimmune disorders. Association of VKHS with autoimmune thyroid disease has been described in the literature in three patients. In the reported case hypothyroidism due to chronic autommune thyroiditis was diagnosed in association with VKHS. Routinely determination of thyroid function in patients with VKHS is recommended.
我们描述了一名29岁印度裔男性中Vogt-小柳-原田综合征（VKHS）与甲状腺功能减退的罕见关联。VKHS是一种罕见的葡萄膜脑膜脑炎综合征，可能具有自身免疫性发病机制。非创伤性葡萄膜炎、无菌性脑膜脑炎、白癜风、脱发和白发是VKHS的主要临床特征。该报告患者出现双侧视力丧失和进行性额部头痛。由于特征性眼科检查结果及无菌性脑膜炎的诊断，VKHS得以确诊。由于自身免疫性发病机制，VKHS可能很少与其他自身免疫性疾病相关。文献中已报道3例VKHS与自身免疫性甲状腺疾病相关。在本报告病例中，与VKHS相关联的慢性自身免疫性甲状腺炎导致了甲状腺功能减退。建议对VKHS患者常规测定甲状腺功能。
