Lim Jae Hee, Lee Yun Nah, Kim Young Seok, Kim Sang Gyune, Jeong Seung Won, Jang Jae Young, Kim Hong Soo, Lee Sae Hwan, Park Tae Kwann
Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Bucheon, Korea.
Korean J Hepatol. 2011 Mar;17(1):61-5. doi: 10.3350/kjhep.2011.17.1.61.
Vogt-Koyanagi-Harada (VKH) disease is a multisystem syndrome characterized by ocular (uveitis and retinal detachment), neurological (headache, tinnitus, and meningitis), and integumentary (vitiligo, alopecia, and poliosis) involvement. Although the pathogenesis of VKH disease is not well understood, an autoimmune T-cell response to a melanocyte-associated antigen is considered to be a cause of VKH disease. The complex immunological response to interferon and ribavirin may induce or exacerbate the autoimmune condition; however, VKH disease is a very rare complication associated with interferon therapy in chronic hepatitis C. We report a case of VKH disease occurring during pegylated interferon-α2b and ribavirin combination therapy for chronic hepatitis C.
伏格特-小柳-原田（VKH）病是一种多系统综合征，其特征为眼部（葡萄膜炎和视网膜脱离）、神经（头痛、耳鸣和脑膜炎）及皮肤（白癜风、脱发和白发）受累。尽管VKH病的发病机制尚不完全清楚，但对黑素细胞相关抗原的自身免疫性T细胞反应被认为是VKH病的病因之一。对干扰素和利巴韦林的复杂免疫反应可能诱发或加重自身免疫状况；然而，VKH病是慢性丙型肝炎干扰素治疗中一种非常罕见的并发症。我们报告1例在聚乙二醇化干扰素-α2b和利巴韦林联合治疗慢性丙型肝炎期间发生VKH病的病例。
