Jörgensen T G, Weis-Fogh U S, Nielsen H H, Olesen H P
Scand J Clin Lab Invest. 1976 Nov;36(7):649-54. doi: 10.1080/00365517609054490.
The hypothesis that the damaging effect on the stomach mucosa of salicylic acid and its derivatives is ascribable to an uncoupling of oxidative phosphorylation has been investigated by testing of mitochondria isolated from the corpus gland area of mini-pig gastric mucosa. Mitochondria, influenced by salicylate or acetylsalicylate (0.7-5.6 mmol/l), demonstrated increased respiration rate, decreased respiratory control ratio, and decreased P/O ratio when tested in vitro. Uncoupling of oxidative phosphorylation occurred at a salicylate concentration between 3.5 and 5.6 mmol/l.
通过对从小型猪胃黏膜胃体腺区分离的线粒体进行测试，研究了水杨酸及其衍生物对胃黏膜的损伤作用归因于氧化磷酸化解偶联的假说。当在体外进行测试时，受水杨酸盐或乙酰水杨酸盐（0.7 - 5.6 mmol/l）影响的线粒体表现出呼吸速率增加、呼吸控制率降低和P/O比值降低。氧化磷酸化的解偶联发生在水杨酸盐浓度为3.5至5.6 mmol/l之间。
