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通过质量调整生存时间评估台湾头盔法所带来的预期效用。

Estimation of expected utility gained from the helmet law in Taiwan by quality-adjusted survival time.

作者信息

Tsauo J Y, Hwang J S, Chiu W T, Hung C C, Wang J D

机构信息

Center for Research of Environmental and Occupational Diseases, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan.

出版信息

Accid Anal Prev. 1999 May;31(3):253-63. doi: 10.1016/s0001-4575(98)00078-5.

Abstract

The objective of this study was to empirically estimate the expected utility gained from the implementation of the 1997 helmet law in Taiwan by using quality-adjusted survival time (QAST). We randomly selected 400 out of 8221 registered cases of head injury and successfully interviewed 99 cases with the index of health-related quality of life (IHRQ). The function of IHRQ was then multiplied with the corresponding survival function to obtain the QAST for head injury. The total utility gained from the helmet law in Taipei within 1 year was estimated by multiplying the expected loss of utility per patient with the number of prevented cases. The results showed that after 80 months of follow-up, the QAST of the injured population was 66.3 quality-adjusted life-months (QALMs), while that of the reference population was 78.7 QALMs. We extrapolated the QAST for total life expectancy by simulating the survival of head injury cases using the life table data from the general population. The life-long utility loss of a head injury case was found to be 4.8 quality-adjusted life-years (QALY). The number of prevented cases during the first year of enforcement of the helmet law was estimated to be 1300 cases in Taipei, which amounted to 6240 QALYs gained. For lack of data, we were unable to calculate the possible gain from helmet on reduction of severity among nonfatal cases with head injury, and the estimation was only a lower bound. We concluded that the QAST approach is a feasible approach applicable to health policy decision-making, especially in cost-utility analysis.

摘要

本研究的目的是通过使用质量调整生存时间(QAST),实证估计台湾实施1997年头盔法所获得的预期效用。我们从8221例登记的头部损伤病例中随机抽取400例,并成功采访了99例具有健康相关生活质量指数(IHRQ)的病例。然后将IHRQ函数与相应的生存函数相乘,以获得头部损伤的QAST。通过将每位患者预期的效用损失与预防病例数相乘,估计了台北市头盔法在1年内获得的总效用。结果显示,随访80个月后,受伤人群的QAST为66.3个质量调整生命月(QALM),而参照人群的QAST为78.7个QALM。我们利用一般人群的生命表数据模拟头部损伤病例的生存情况,推断出总预期寿命的QAST。发现一例头部损伤病例的终身效用损失为4.8个质量调整生命年(QALY)。估计头盔法实施第一年台北市预防的病例数为1300例,相当于获得了6240个QALY。由于缺乏数据,我们无法计算头盔对降低非致命性头部损伤病例严重程度可能带来的收益,该估计只是一个下限。我们得出结论,QAST方法是一种适用于卫生政策决策的可行方法,特别是在成本效用分析中。

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