Koulaouzidou E A, Margelos J, Beltes P, Kortsaris A H
Department of Dental Pathology and Therapeutics, Dental School, Aristotle University, Thessaloniki, Greece.
J Endod. 1999 Jan;25(1):21-3. doi: 10.1016/S0099-2399(99)80393-8.
The cytotoxic effects of neutral and alkaline EDTA solutions were evaluated and compared with those of sodium hypochlorite solution using an established cell line: L929. Cytotoxicity was assessed by a quantitative technique at five observation periods (1, 3, 6, 12, and 24 h). All tested agents showed moderate to severe cytotoxicity in the present experimental model in a concentration-dependent manner.
使用已建立的细胞系L929评估并比较了中性和碱性乙二胺四乙酸（EDTA）溶液与次氯酸钠溶液的细胞毒性作用。在五个观察期（1、3、6、12和24小时）通过定量技术评估细胞毒性。在本实验模型中，所有测试试剂均呈浓度依赖性地表现出中度至重度细胞毒性。
