Zider A, Paumard-Rigal S, Frouin I, Silber J
Laboratoire de Génétique Quantitative et Moléculaire, Institut Jacques Monod, Paris, France.
J Neurogenet. 1998 Mar;12(2):87-99. doi: 10.3109/01677069809167258.
The vestigial (vg) gene of Drosophila melanogaster encodes a novel nuclear protein which is required for wing formation but its function is not restricted to this developmental process. In this report, we have examined the possible role of vestigial in the formation of the peripheral nervous system. We found that most vestigial mutants display ectopic or missing macrochaetae. We also show that vestigial interacts in a dose dependant manner with different alleles of the scute gene and with the extramacrochaetae gene and that mis-expression of the vestigial gene in the wing disc increases the domain of scute expression and allows the formation of supernumerary ectopic bristles. From these results, we conclude that vestigial affects scute expression and plays a role in the differentiation of the peripheral nervous system.
果蝇的残翅（vg）基因编码一种新型核蛋白，该蛋白是翅膀形成所必需的，但其功能并不局限于这一发育过程。在本报告中，我们研究了残翅基因在周围神经系统形成过程中可能发挥的作用。我们发现，大多数残翅突变体表现出异位或缺失的大刚毛。我们还表明，残翅基因与scute基因的不同等位基因以及extra macrochaetae基因以剂量依赖的方式相互作用，并且残翅基因在翅盘中的错误表达会增加scute基因的表达域，并允许形成额外的异位刚毛。从这些结果中，我们得出结论，残翅基因影响scute基因的表达，并在周围神经系统的分化中发挥作用。
