Abu-Issa R, Cavicchi S
Department of Biology, University of Bologna, Italy.
J Neurogenet. 1996 Sep;10(4):239-46. doi: 10.3109/01677069609083465.
In this paper we describe the results of genetic analysis of the vestigial locus by studying its interactions with hairy and Notch loci in Drosophila melanogaster. Different vestigial alleles in homo- and heterozygous combination with different hairy alleles show synergism in increasing both cell death and formation of ectopic bristles and produce ectopic veins. Interactions between N and vg also show synergism in increasing cell death and formation of ectopic bristles. Only synergism in cell death is seen between h and N. The interactions indicate that vg product plays a role in the differentiation of epidermal and neural cells of the wing disc by interacting with N and h products either directly or indirectly. Mechanisms of molecular interactions among the three loci are discussed.
在本文中，我们通过研究果蝇中残翅基因座与刚毛和Notch基因座的相互作用，描述了残翅基因座的遗传分析结果。不同的残翅等位基因与不同的刚毛等位基因以纯合和杂合组合形式存在时，在增加细胞死亡和异位刚毛形成方面表现出协同作用，并产生异位翅脉。N和vg之间的相互作用在增加细胞死亡和异位刚毛形成方面也表现出协同作用。h和N之间仅在细胞死亡方面表现出协同作用。这些相互作用表明，vg产物通过直接或间接与N和h产物相互作用，在翅盘表皮和神经细胞的分化中发挥作用。文中还讨论了这三个基因座之间分子相互作用的机制。
