Kroboth P D, Salek F S, Pittenger A L, Fabian T J, Frye R F
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA 15261, USA.
J Clin Pharmacol. 1999 Apr;39(4):327-48. doi: 10.1177/00912709922007903.
Dehydroepiandrosterone (DHEA) and its sulfated metabolite DHEA-S are endogenous hormones secreted by the adrenal cortex in response to adrenocorticotrophin (ACTH). Much has been published regarding potential effects on various systems. Despite the identification of DHEA and DHEA-S more than 50 years ago, there is still considerable controversy as to their biological significance. This article reviews the metabolism and physiology of DHEA and DHEA-S, the influence of age and gender on concentrations, and changes in endogenous concentrations associated with disease states and other factors, including diet and exercise. This article is unique in that it also summarizes the influence of drugs on DHEA and DHEA-S concentrations, as well as concentrations of DHEA and DHEA-S observed after the administration of DHEA by various routes. Sections of the article specifically address DHEA and DHEA-S concentrations as they relate to stress, central nervous system function and psychiatric disorders, insulin sensitivity, immunological function, and cardiovascular disorders.
脱氢表雄酮（DHEA）及其硫酸化代谢产物硫酸脱氢表雄酮（DHEA-S）是肾上腺皮质响应促肾上腺皮质激素（ACTH）分泌的内源性激素。关于它们对各种系统的潜在影响，已有大量文献发表。尽管DHEA和DHEA-S在50多年前就已被发现，但关于它们的生物学意义仍存在相当大的争议。本文综述了DHEA和DHEA-S的代谢与生理学、年龄和性别对其浓度的影响，以及与疾病状态和其他因素（包括饮食和运动）相关的内源性浓度变化。本文的独特之处在于，它还总结了药物对DHEA和DHEA-S浓度的影响，以及通过各种途径给予DHEA后观察到的DHEA和DHEA-S浓度。文章各部分特别讨论了与应激、中枢神经系统功能和精神障碍、胰岛素敏感性、免疫功能以及心血管疾病相关的DHEA和DHEA-S浓度。
