Collomp K, Buisson C, Lasne F, Collomp R
Laboratoire CIAMS, EA 4532, Université Paris Sud - Université Orléans, France; Département des Analyses, Agence Française de Lutte contre le Dopage, Chatenay-Malabry, France.
Département des Analyses, Agence Française de Lutte contre le Dopage, Chatenay-Malabry, France.
J Steroid Biochem Mol Biol. 2015 Jan;145:206-12. doi: 10.1016/j.jsbmb.2014.03.005. Epub 2014 Apr 2.
The dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) concentrations during acute and chronic exercise (training) have been investigated only fairly recently. DHEA is generally preferred to DHEA-S for exploring the acute exercise repercussions in laboratory or field tests because of its shorter elimination half-life. Conversely, DHEA-S is preferred to estimate chronic adaptations. Both can be measured noninvasively in saliva, and it is therefore possible to follow these hormone responses in elite athletes during competitive events and in healthy and pathological populations, without imposing additional stress. Indeed, the correlation between saliva and serum concentrations is high for steroid hormones, both at rest and during exercise. In this review, we will first summarize the current knowledge on the DHEA/DHEA-S responses to exercise and examine the potential modulating factors: exercise intensity, gender, age, and training. We will then discuss the ergogenic effects that athletes expect from the exogenous administration of DHEA and the antidoping methods of analysis currently used to detect this abuse.
直到最近才开始研究急性和慢性运动（训练）过程中脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEA-S）的浓度。在实验室或现场测试中探索急性运动的影响时，由于DHEA的消除半衰期较短，通常比DHEA-S更受青睐。相反，在估计慢性适应性方面，DHEA-S更受青睐。两者都可以通过唾液进行无创测量，因此，在竞技赛事期间，精英运动员以及健康和患病人群中，无需施加额外压力就能跟踪这些激素反应。事实上，无论是在静息状态还是运动期间，唾液和血清中类固醇激素浓度之间的相关性都很高。在这篇综述中，我们将首先总结目前关于DHEA/DHEA-S对运动反应的知识，并研究潜在的调节因素：运动强度、性别、年龄和训练。然后，我们将讨论运动员期望通过外源性给予DHEA获得的促力效应，以及目前用于检测这种滥用行为的反兴奋剂分析方法。
