Chamberlain R S, Huber K, White J C, Travaglino-Parda R
Department of Surgery, George Washington University Medical Center, Washington, DC, USA.
Am J Clin Oncol. 1999 Apr;22(2):131-5. doi: 10.1097/00000421-199904000-00005.
Apocrine gland carcinoma is a rare form of sweat gland neoplasm with a distinctive cytologic appearance. Although the region of the axilla remains the most common site for these tumors, apocrine gland carcinoma of the anogenital region, eyelid, ear, chest, wrist, lip, foot, toe, and finger have been reported. Classically, these slow-growing lesions present as painless, colorless or reddish, firm or cystic nodules. More than half of the reported patients with apocrine carcinoma had lymph node metastases at the time of diagnosis. Wide local excision is standard therapy for these lesions. A therapeutic lymph node dissection is indicated for confirmed lymph node metastases and may have a role in the setting of a large or highly aggressive tumor with narrow surgical margins. Although apocrine gland carcinoma responds poorly to chemotherapy, adjuvant radiotherapy may be used in advanced local or regional disease. The authors describe a 69-year-old man with a large recurrent apocrine gland carcinoma of the axilla treated with en bloc excision with axillary dissection and offer a pertinent review of the English literature and recommendations for treatment.
顶泌汗腺癌是一种罕见的汗腺肿瘤，具有独特的细胞学表现。虽然腋窝区域仍是这些肿瘤最常见的部位，但也有报道称发生于生殖区域、眼睑、耳部、胸部、腕部、唇部、足部、脚趾和手指的顶泌汗腺癌。典型情况下，这些生长缓慢的病变表现为无痛性、无色或微红、质地硬或呈囊性的结节。在已报道的顶泌汗腺癌患者中，超过半数在诊断时已有淋巴结转移。广泛局部切除是这些病变的标准治疗方法。对于确诊有淋巴结转移的患者，需进行治疗性淋巴结清扫，对于手术切缘窄的大肿瘤或侵袭性强的肿瘤，淋巴结清扫可能也有作用。虽然顶泌汗腺癌对化疗反应不佳，但对于局部晚期或区域病变，可采用辅助放疗。作者描述了一名69岁男性，患有复发性巨大腋窝顶泌汗腺癌，接受了腋窝整块切除及腋窝淋巴结清扫治疗，并对英文文献进行了相关综述及提出了治疗建议。
