Rillema J A, Mulder J A
Prostaglandins Med. 1978 Jul;1(1):31-8. doi: 10.1016/0161-4630(78)90074-5.
In the phospholipid fractions, arachidonic acid represented a several fold higher percentage of fatty acids from DMBA-induced tumors and in mammary glands from midpregnant rats when compared to mammary glands from virgin rats. Arachidonic acid was not present in measurable quantities in the neutral lipid fractions of mammary glands from virgin rats. The arachidonic acid in the neutral lipid fraction of mammary glands from midpregnant rats was only detectable in the triglyceride-sterol ester fraction, but in that fraction less than 1% of the fatty acids were arachidonic acid. In the neutral lipids of the DMBA-induced tumors, it was of particular interest that a high proportion (19%) of the fatty acids in the diglyceride fraction consisted of arachidonic acid; no arachidonic acid was detected in the diglycerides of the normal tissues.
在磷脂组分中，与未孕大鼠的乳腺相比，花生四烯酸在二甲基苯并蒽（DMBA）诱导的肿瘤以及妊娠中期大鼠乳腺中的脂肪酸中所占百分比要高出几倍。未孕大鼠乳腺的中性脂质组分中未检测到可测量量的花生四烯酸。妊娠中期大鼠乳腺中性脂质组分中的花生四烯酸仅在甘油三酯 - 甾醇酯组分中可检测到，但在该组分中，脂肪酸中花生四烯酸的含量不到1%。在DMBA诱导的肿瘤的中性脂质中，特别值得注意的是，甘油二酯组分中19%的脂肪酸为花生四烯酸；在正常组织的甘油二酯中未检测到花生四烯酸。
