Segnan N, Tanturri G
Tumori. 1976 Jul-Aug;62(4):377-85. doi: 10.1177/030089167606200404.
A previous report has shown that in the non-metropolitan areas of the province of Torino the incidence of cancer of the larynx in men during the period 1965-1969, although lower than in the town of Torino and its suburbs, was 3-6 times higher than in Great Britain, Norway, Sweden and Denmark. In the present study the distribution of these cancers was investigated in the 12 ecological areas and/or subareas forming the non-metropolitan areas of the province. A similar study for bladder cancer in adult men and all cancers (including leukaemias) in children, is also reported. In subareas 36, 37 and 42 of ecological area 01 (i.e., located NW of the capital and its suburbs) as well as in area 02 (located North of the province, around the town of Ivrea) a significant excess of laryngeal cancers have been diagnosed in adult men during the period 1965-1969. Cancer of the bladder was found in excess in men residing in subareas 37 and 43 of area 01 (geographically related to the town of Ciriè, where an epidemic of bladder cancer was recognized among workers of a chemical factory where 2-naphthylamine and benzidine have been widely used in the past), as well as in men residing in area 02. In addition, laryngeal cancer was found in excess among residents in Balangero (where a large asbestos-chrysotilemine has been in operation for a long time) and adjacent towns (observed 12, expected 5.14, p less than 0.01). Bladder cancer was particularly frequent among residents in Ciriè and adjacent towns (19 cases vs. 9.18 expected, p less than 0.01) as well as in those residing in Ivrea and adjacent towns (24 vs. 14.61 expected, p less than 0.02). On the contrary, the whole area situated East and South of Torino and its suburbs seems to be a low-incidence area for both laryngeal and bladder cancer. For both tumor types the highest incidence was found in the town of Torino. Men residing in the 23 suburbs of Torino showed a high incidence of laryngeal cancer and a low incidence of bladder cancer. Cancers in children were fairly uniformly distributed throughout the whole province, including the capital.
先前的一份报告显示，在1965 - 1969年期间，都灵省的非都市地区男性喉癌发病率虽低于都灵市及其郊区，但比英国、挪威、瑞典和丹麦高3至6倍。在本研究中，对该省非都市地区的12个生态区和/或分区中这些癌症的分布情况进行了调查。还报告了一项针对成年男性膀胱癌和儿童所有癌症（包括白血病）的类似研究。在生态区01的36、37和42分区（即位于省会及其郊区西北）以及02区（位于该省北部，围绕伊夫雷亚镇），1965 - 1969年期间成年男性中诊断出的喉癌显著过多。居住在01区37和43分区（在地理上与奇列镇相关，过去在该镇一家化工厂的工人中曾发现膀胱癌流行，该化工厂曾广泛使用2 - 萘胺和联苯胺）以及02区的男性中发现膀胱癌过多。此外，在巴兰杰罗（那里有一家大型温石棉矿长期运营）及其相邻城镇的居民中发现喉癌过多（观察到12例，预期5.14例，p小于0.01）。奇列及其相邻城镇的居民中膀胱癌尤为常见（19例 vs.预期9.18例，p小于0.01），伊夫雷亚及其相邻城镇的居民中也是如此（24例 vs.预期14.61例，p小于0.02）。相反，都灵市及其郊区以东和以南的整个地区似乎是喉癌和膀胱癌的低发区。对于这两种肿瘤类型，最高发病率都出现在都灵市。居住在都灵23个郊区的男性喉癌发病率高，膀胱癌发病率低。儿童癌症在全省包括省会在内分布相当均匀。
