Shields J A, Rodrigues M M, Sarin L K, Tasman W S, Annesley W H
Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Sep-Oct;81(5):871-81.
This study has shown that lipofuscin pigment may accumulate in RPE cells and macrophages over several types of benign and malignant choroidal tumors. The color of the pigment, however, varies with the nature and color of the underlying lesion. On the surface of deeply pigmented tumors the lipofuscin pigment may produce an orange color, whereas over amelanotic lesions it may appear brown or reddish-brown. On the surface of vascular tumors, such as choroidal hemangiomas, the lipofuscin is almost invisible ophthalmoscopically but may be demonstrated with fluorescein angiography. Although the presence of such pigment accumulation is suggestive of a malignant melanoma, it is not diagnostic and may occur over benign simulating lesions as well.
这项研究表明，在多种良性和恶性脉络膜肿瘤中，脂褐素色素可能会在视网膜色素上皮（RPE）细胞和巨噬细胞中积聚。然而，色素的颜色会因潜在病变的性质和颜色而有所不同。在色素沉着较深的肿瘤表面，脂褐素色素可能呈现橙色，而在无色素性病变上，它可能呈现棕色或红棕色。在血管性肿瘤表面，如脉络膜血管瘤，脂褐素在检眼镜下几乎不可见，但荧光素血管造影可能显示出来。虽然这种色素积聚的存在提示恶性黑色素瘤，但它并非诊断性的，也可能出现在良性模拟病变上。
