McGeer P L, McGeer E G
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
J Leukoc Biol. 1999 Apr;65(4):409-15. doi: 10.1002/jlb.65.4.409.
We briefly describe the similarities and differences between a systemic and a local immune reaction and review the evidence that the latter occurs in Alzheimer's disease (AD) brains. The evidence comes mainly from studies on the complement system, microglia, and cytokines, all of which are important actors in the inflammatory process. The evidence is now overwhelming that the complement proteins and many of the mediators of inflammation are produced locally by brain cells. We will mention briefly the many epidemiological studies indicating that the use of anti-inflammatory drugs reduces the incidence and slows the progress of AD. Mention will also be made of some recent work on animal models of possible relevance to AD and inflammation.
我们简要描述全身免疫反应和局部免疫反应之间的异同，并综述后者发生在阿尔茨海默病（AD）大脑中的证据。这些证据主要来自对补体系统、小胶质细胞和细胞因子的研究，它们都是炎症过程中的重要参与者。现在有压倒性的证据表明补体蛋白和许多炎症介质是由脑细胞在局部产生的。我们将简要提及许多流行病学研究，这些研究表明使用抗炎药物可降低AD的发病率并减缓其进展。还将提及一些最近关于可能与AD和炎症相关的动物模型的研究工作。
