1987年至1992年日本九州地区由SRSV引起的肠胃炎暴发：四起与食用牡蛎有关的暴发事件。

Outbreaks of gastroenteritis caused by SRSVs from 1987 to 1992 in Kyushu, Japan: four outbreaks associated with oyster consumption.

作者信息

Otsu R

机构信息

Fukuoka Institute of Health and Environmental Sciences, Dazaifu, Japan.

出版信息

Eur J Epidemiol. 1999 Feb;15(2):175-80. doi: 10.1023/a:1007543924543.

DOI:10.1023/a:1007543924543

PMID:10204648

Abstract

From 1987 to 1992, 18 outbreaks of acute non-bacterial gastroenteritis occurred in Kyushu district. The most common symptoms were diarrhea, vomiting, nausea and abdominal cramp. Small round structured viruses (SRSVs) were detected in 52 (44.8%) of 116 stool samples from 17 outbreaks by the electron microscopy (EM) method, and a significant increase in the antibody level was noted in 42 (80.7%) of 52 paired serum samples from 12 outbreaks by the immune electron microscopy (IEM) method and in 18 (51.4%) of 35 samples from 8 outbreaks by the western blot (WB) method. However, according to the WB method, antigen-antibody reaction was not observed to reference antigen strips (SRSV-9/Tokyo 86-510, 63 kDa) in three of the 8 outbreaks. The detected virus was regarded as an etiologic agent for these outbreaks. In four of 5 outbreaks which appeared associated with eating raw oysters, there was a close relation between SRSV infection and consumption of raw oysters.

摘要

1987年至1992年期间，九州地区发生了18起急性非细菌性肠胃炎疫情。最常见的症状为腹泻、呕吐、恶心和腹部绞痛。通过电子显微镜（EM）方法，在17起疫情的116份粪便样本中的52份（44.8%）中检测到小圆结构病毒（SRSV）；通过免疫电子显微镜（IEM）方法，在12起疫情的52份配对血清样本中的42份（80.7%）中观察到抗体水平显著升高；通过蛋白质印迹法（WB），在8起疫情的35份样本中的18份（51.4%）中观察到抗体水平显著升高。然而，根据蛋白质印迹法，在8起疫情中的3起中，未观察到与参考抗原条带（SRSV-9/东京86-510，63 kDa）的抗原-抗体反应。检测到的病毒被视为这些疫情的病原体。在5起似乎与食用生牡蛎有关的疫情中，有4起SRSV感染与食用生牡蛎之间存在密切关联。