Fischer U, Hommel H, Nowak W, von Dorsche H H, Sill U, Lippert H
Acta Biol Med Ger. 1976;35(10):1279-91.
A part of the intrapancreatic nerve fibres of dogs show 1-2 months after bilateral truncal vagotomy a decay of the medullary sheath; in addition, the histochemically demonstrable insulin content of the B-cells is reduced. These animals do no longer react to oral glucose administration or feeding a meat meal with a reflectoric early rise of plasma insulin concentration and of exocrine functional parameters (all the animals were bearing exocrine pancreas fistulas). The glucose tolerance and and the decrease of free fatty acids in serum were restricted. Also, the content of bicarbonate and protein in the pancreatic juice and the insulin secretion of vagotomized animals are strongly reduced in the subsequent test phase (up to 120 min) following oral or i.v. glucose administration and after feeding meat. The inhibition of exocrine volume secretion following i.v. glucose administration was enhanced by the intervention. The findings confirm the involvement of the N. vagus in the mechanisms of the enteroinsular axis that becomes active together with exocrine gastro- and duodenopancreatic reflexes to any kind of physiological enteral stimulation.
双侧迷走神经干切断术后1 - 2个月，犬胰腺内部分神经纤维出现髓鞘退变；此外，B细胞中组织化学可检测到的胰岛素含量降低。这些动物不再对口服葡萄糖或喂食肉餐产生反应，血浆胰岛素浓度和外分泌功能参数不再出现反射性早期升高（所有动物均有外分泌胰腺瘘）。葡萄糖耐量以及血清中游离脂肪酸的降低受到限制。此外，在口服或静脉注射葡萄糖以及喂食肉类后的后续测试阶段（长达120分钟），迷走神经切断动物的胰液中碳酸氢盐和蛋白质含量以及胰岛素分泌也大幅降低。静脉注射葡萄糖后外分泌量分泌的抑制因干预而增强。这些发现证实了迷走神经参与肠胰岛轴的机制，该机制与任何类型的生理性肠内刺激引发的胃肠和十二指肠胰腺外分泌反射一起激活。
