Fischer U, Nowak W, Freyse E J, Hommel H, Sill U, Lippert H
Diabete Metab. 1982 Jun;8(2):115-20.
The mechanism of reflex plasma insulin responses after oral stimulation and the influence of autonomic control on glucose- and meal -induced insulin secretion needs to be elucidated. Dogs with chronic pancreatic fistulas were studied two months after selective pancreatic denervation or bilateral truncal vagotomy and compared with fistulated controls. The normal glucose- and amino acid-independent insulinogenic reflex after an oral glucose load or after a meal was inhibited in the experimental groups. Glucose-related insulin secretion (oral or intravenous loads) and glucose tolerance were clearly reduced after vagotomy, but only partly diminished in the denervated animals. The plasma insulin increase after meat ingestion was inhibited in both experimental groups. It is concluded that the B-cells work under integrated tonic control of both the vagal and the sympathetic systems. Independent of this control, a vago-vagal insulinogenic reflex is initiated by enteric stimuli. These two mechanisms might be considered as part of the gastroentero-pancreatic axis in a broader sense.
口服刺激后反射性血浆胰岛素反应的机制以及自主神经控制对葡萄糖和进餐诱导的胰岛素分泌的影响有待阐明。对患有慢性胰瘘的狗在选择性胰腺去神经支配或双侧迷走神经干切断术后两个月进行研究，并与瘘管对照动物进行比较。实验组中口服葡萄糖负荷或进餐后正常的不依赖葡萄糖和氨基酸的胰岛素生成反射受到抑制。迷走神经切断术后，与葡萄糖相关的胰岛素分泌（口服或静脉负荷）和葡萄糖耐量明显降低，但在去神经支配的动物中仅部分降低。两个实验组摄入肉类后血浆胰岛素的增加均受到抑制。结论是，B细胞在迷走神经和交感神经系统的整合性紧张性控制下发挥作用。独立于这种控制之外，肠道刺激可引发迷走-迷走胰岛素生成反射。从更广泛的意义上讲，这两种机制可被视为胃肠胰轴的一部分。
