Fischer U, Hommel H, Ziegler M, Nowak W, von Dorsche H H
Endokrinologie. 1976;68(3):327-37.
On pancreatic fistula dogs, in the pancreatic juice, immunoreactive insulin has been identified. Insulin excretion is shown to be inhibited by an intravenous glucose load and to be stimulated in a biphasic manner by an oral glucose load or by ingestion of mashed meat. Insulin excretion is reduced 2 months after bilateral truncular vagotomy and the reaction to both oral stimuli is abolished. -- There is no statistical correlation between pancreatic juice insulin and blood glucose, plasma IRI, or plasma amino nitrogen concentrations. Single extrainsular B-cells shown by histologic examination are suggested to be the source of pancreatic juice insulin. Compared to insulin secreted into the portal blood flow, insulin in the pancreatic juice amounts to only 0.1--0.2% of the daily secretory rate of the islets of Langerhans.
在胰腺瘘犬的胰液中，已鉴定出免疫反应性胰岛素。静脉注射葡萄糖负荷可抑制胰岛素分泌，口服葡萄糖负荷或摄入碎肉则以双相方式刺激胰岛素分泌。双侧迷走神经干切断术后2个月，胰岛素分泌减少，对两种口服刺激的反应均消失。——胰液胰岛素与血糖、血浆IRI或血浆氨基氮浓度之间无统计学相关性。组织学检查显示的单个胰岛外B细胞被认为是胰液胰岛素的来源。与分泌到门静脉血流中的胰岛素相比，胰液中的胰岛素仅占胰岛每日分泌率的0.1 - 0.2%。
