Nowak W, Fischer U, Hommel H, Lippert H, Sill U, Reding R
Zentralbl Chir. 1978;103(14):923-31.
In dogs supplied with chronic pancreatic fistulas, there is no change of the basal exocrine secretion of volume three weeks after a bilateral truncular vagotomy. The normal initial reflex secretion during meal ingestion or glucose loading are abolished. On the whole, the secretory activity is reduced by about 50% after feeding. Secretions of volume and of enzyme protein are inhibited to the same extent, but that of bicarbonate is more strongly influenced. After vagotomy the inhibitory influence on all secretions of a rabidly produced hyperglycemia is reinforced. In pancreatic juice there is immunocreactive insulin activity (less than 1% fo the daily secreted amount). Insulin secreted in pancreatic juice after feeding is strongly reduced after vagotomy. This is the best reproducible proof of an influence on the exocrine pancreatic function of vagotomy.
在患有慢性胰瘘的犬中，双侧迷走神经干切断术后三周，基础外分泌量无变化。进食或葡萄糖负荷时正常的初始反射性分泌消失。总体而言，进食后分泌活性降低约50%。容量分泌和酶蛋白分泌受到同等程度的抑制，但碳酸氢盐分泌受到的影响更强。迷走神经切断术后，快速产生的高血糖对所有分泌的抑制作用增强。胰液中存在免疫反应性胰岛素活性（低于每日分泌量的1%）。迷走神经切断术后，进食后胰液中分泌的胰岛素大幅减少。这是迷走神经切断术对外分泌胰腺功能有影响的最佳可重复证据。
