Levine D, Barnes P D
Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Radiology. 1999 Mar;210(3):751-8. doi: 10.1148/radiology.210.3.r99mr47751.
To establish the appearance of normal fetal cortical development in utero and compare it with the appearance of abnormal cortical development.
Magnetic resonance (MR) images of the brain in 53 normal and 40 abnormal fetuses at 14-38 weeks gestational age (GA) were reviewed. The GAs at the time of MR imaging visualization of the fissures or sulci were compared with the GA guidelines based on neuroanatomic studies.
In normal fetuses, the sulcation landmarks appeared on MR images in the order predicted by using anatomic studies, with a 0-8-week lag in the MR imaging visualization of the sulci compared with the reported time of visualization of the sulci in anatomic specimens. When landmarks were grouped by range of GAs, the expected MR imaging sulcation landmarks in the group with younger GAs than the actual GA were seen in 50 of 53 (94%) normal fetuses, in five of nine fetuses (56%, P < .05) with isolated mild ventriculomegaly, and in 24 of 31 fetuses (77%, P < .05) with other CNS anomalies.
Normal fetal cortical maturation at MR imaging follows a predictable course that is slightly delayed compared with that described in neuroanatomic specimens. This maturation is often further delayed in fetuses with CNS abnormalities.
确定正常胎儿宫内皮质发育的表现，并将其与异常皮质发育的表现进行比较。
回顾了53例正常胎儿和40例异常胎儿在孕14 - 38周时的脑部磁共振（MR）图像。将MR成像显示脑沟或脑回时的孕周与基于神经解剖学研究的孕周指南进行比较。
在正常胎儿中，脑沟标志在MR图像上按解剖学研究所预测的顺序出现，与解剖标本中报道的脑沟显示时间相比，MR成像显示脑沟的时间滞后0 - 8周。当按孕周范围对标志进行分组时，孕周小于实际孕周组中预期的MR成像脑沟标志在53例正常胎儿中的50例（94%）、9例孤立性轻度脑室扩大胎儿中的5例（56%，P <.05）以及31例其他中枢神经系统异常胎儿中的24例（77%，P <.05）中可见。
MR成像时正常胎儿皮质成熟遵循可预测的过程，与神经解剖标本中描述的相比略有延迟。在中枢神经系统异常的胎儿中，这种成熟通常会进一步延迟。
