Rebbeck T R, Walker A H, Jaffe J M, White D L, Wein A J, Malkowicz S B
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Cancer Epidemiol Biomarkers Prev. 1999 Apr;8(4 Pt 1):283-7.
The glutathione S-transferases (GSTs) are involved in the metabolism of numerous potential prostate carcinogens. Common homozygous germ-line deletions exist in the genes that encode GST-mu (GSTM1) and GST-theta (GSTT1) and preclude enzyme expression. To evaluate whether GSTM1 and/or GSTT1 contribute to prostate cancer (CaP) etiology, we studied 237 incident CaP cases and 239 age- and race-matched controls. The probability of having CaP was increased in men who had nondeleted (functional) genotypes at GSTT1 (odds ratio, 1.83; 95% confidence interval, 1.19-2.80) but not GSTM1 (odds ratio, 1.07; 95% confidence interval, 0.74-1.55). No interaction of these genes in CaP etiology was observed. GST-theta is highly expressed in the prostate and can produce genotoxic effects upon exposure to specific carcinogens. These results suggest that GSTT1 is associated with CaP risk.
谷胱甘肽S-转移酶（GSTs）参与多种潜在前列腺致癌物的代谢。编码GST-μ（GSTM1）和GST-θ（GSTT1）的基因存在常见的纯合子种系缺失，这会阻止酶的表达。为了评估GSTM1和/或GSTT1是否对前列腺癌（CaP）的病因有影响，我们研究了237例新发CaP病例和239例年龄及种族匹配的对照。GSTT1基因具有非缺失（功能性）基因型的男性患CaP的概率增加（优势比，1.83；95%置信区间，1.19 - 2.80），而GSTM1基因则无此现象（优势比，1.07；95%置信区间，0.74 - 1.55）。未观察到这些基因在CaP病因学上的相互作用。GST-θ在前列腺中高度表达，暴露于特定致癌物时可产生基因毒性作用。这些结果表明GSTT1与CaP风险相关。
