Kang T C, Seo J, Song S H, Kim Y W, Yi S J, Kim J S, Won M H, Lee I S, Lee H S
Department of Veterinary Anatomy, College of Veterinary Medicine, Seoul National University, South Korea.
Anat Histol Embryol. 1999 Mar;28(1):41-3. doi: 10.1046/j.1439-0264.1999.00160.x.
Pericellular arborization is reported to be the self-regulating structure in sensory ganglia. Although the calcitonin gene-related peptide (CGRP) or substance P (SP) immunoreactive pericellular arborization appeared in the sensory ganglia, there was no available information that CGRP and SP colocalize in this structure. As the attempts to resolve the question described above, the present study was undertaken to identify the coexistence of CGRP and SP in pericellular arborizations of the goat nodose and trigeminal ganglia by double immunohistochemistry. As the results show, CGRP immunoreactivity was present in every pericellular arborization containing SP immunoreactivity in trigeminal ganglia, however, pericellular network containing CGRP or SP immunoreactivity was not present in nodose ganglia. Unexpectedly, a few small satellite elements were observed to contain intense CGRP and SP immunoreactivity at the periphery of CGRP and SP immunoreactive neurones in nodose ganglia. Therefore, these results suggest that CGRP and SP coexist in pericellular arborizations, and that satellite cell as well as pericellular arborization may be involved in intraganglionic regulation of goat sensory ganglia.
据报道，细胞周围分支是感觉神经节中的自我调节结构。尽管降钙素基因相关肽（CGRP）或P物质（SP）免疫反应性细胞周围分支出现在感觉神经节中，但尚无关于CGRP和SP在该结构中共定位的信息。为了解决上述问题，本研究通过双重免疫组织化学来鉴定山羊结状神经节和三叉神经节细胞周围分支中CGRP和SP的共存情况。结果显示，在三叉神经节中，每个含有SP免疫反应性的细胞周围分支中都存在CGRP免疫反应性，然而，在结状神经节中不存在含有CGRP或SP免疫反应性的细胞周围网络。出乎意料的是，在结状神经节中，在CGRP和SP免疫反应性神经元周围观察到一些小的卫星细胞含有强烈的CGRP和SP免疫反应性。因此，这些结果表明CGRP和SP在细胞周围分支中共存，并且卫星细胞以及细胞周围分支可能参与山羊感觉神经节的神经节内调节。
