Tandon A, Nagpaul J P, Bandhu H, Singh N, Dhawan D K
Department of Biochemistry, Panjab University, Chandigarh, India.
Biol Trace Elem Res. 1999 Apr;68(1):51-62. doi: 10.1007/BF02784396.
Lithium carbonate at the dose level of 1.1 g/kg was administered in diet to normal (18% protein), low-protein- (LP; 8%) and high-protein (HP; 30% diet)-fed rats for a period of 1 mo. The LP diet resulted in a significant decrease in the hepatic levels of zinc, iron, copper, manganese, calcium, and serum levels of calcium and sodium. The HP diet caused a marked decrease in copper and calcium levels in liver, but an increase in potassium levels in serum was observed. Lithium treatment to normal rats led to a significant reduction in the hepatic contents of zinc, copper, potassium, calcium, and serum contents of potassium and sodium, whereas an elevation in serum contents of calcium was noticed. Administration of lithium to protein-deficient rats increased the hepatic concentration of manganese and serum concentration of calcium and the levels almost reached the normal limits. On the other hand, there was a marked depression in potassium contents in the serum of LP- as well as HP-fed rats following lithium treatment when compared to LP and HP groups, respectively.
将碳酸锂以1.1克/千克的剂量添加到正常（蛋白质含量18%）、低蛋白（LP；8%）和高蛋白（HP；30%）饮食喂养的大鼠的饲料中，持续1个月。低蛋白饮食导致肝脏中锌、铁、铜、锰、钙水平以及血清中钙和钠水平显著降低。高蛋白饮食使肝脏中铜和钙水平显著降低，但血清中钾水平升高。对正常大鼠进行锂处理导致肝脏中锌、铜、钾、钙含量以及血清中钾和钠含量显著降低，而血清中钙含量升高。对蛋白质缺乏的大鼠施用锂增加了肝脏中锰的浓度以及血清中钙的浓度，且这些水平几乎达到正常范围。另一方面，与LP组和HP组相比，锂处理后，LP饮食和HP饮食喂养的大鼠血清中的钾含量显著降低。
