Dzegilenko N B, Riabova N M, Zinchenko E Ia, Korchagin V B
Antibiotiki. 1976 Nov;21(11):968-70.
7-Phenoxyacetamidodesacetoxycephalosporanic acid, an intermediate product in synthesis of cephalexin, was prepared by oxydation of phenoxymethylpenicillin into the respective sulphoxide and transformation of the latter. The UV-spectra of the reaction products were studied. A quantitative method is proposed for determination of 7-phenoxyacetamidodesacetoxycephalosporanic acid in the finished products based on estimation os the coefficient of specific extinction of the ethanol solutions at a wave length of 268 um in the UV-spectrum region in combination with semiquantitative estimation of the admixtures with the method of thin-layer chromatography.
7-苯氧乙酰胺基去乙酰氧基头孢烷酸是头孢氨苄合成中的一种中间产物，它是通过将苯氧甲基青霉素氧化成相应的亚砜并对后者进行转化而制得的。研究了反应产物的紫外光谱。提出了一种定量方法，该方法基于在紫外光谱区域中在268纳米波长下乙醇溶液的比消光系数的估算，并结合薄层色谱法对杂质进行半定量估算，用于测定成品中的7-苯氧乙酰胺基去乙酰氧基头孢烷酸。
