Mester Z, Horváth G, Vitányi G, Lelik L, Fodor P
Chemistry and Biochemistry Department of University of Horticulture and Food Industry, Budapest, Hungary.
Rapid Commun Mass Spectrom. 1999;13(5):350-3. doi: 10.1002/(SICI)1097-0231(19990315)13:5<350::AID-RCM490>3.0.CO;2-V.
A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) using thioglycol methylate (TGM) was measured. The detection limit for the derivatized DMA and MMA using the GC/MS method are 0.95 and 0.8 ng cm-3, respectively. This simple and rapid method has good precision and accuracy. Fragmentation routes of derivatized MMA and DMA are suggested on accurate mass measurements.
已开发出一种气相色谱/质谱（GC/MS）方法来测定人类尿液样本中的两种甲基化砷物种。测量了使用硫代乙醇酸甲酯（TGM）对二甲基砷酸（DMA）和一甲基砷酸（MMA）进行衍生化的产率。使用GC/MS方法对衍生化的DMA和MMA的检测限分别为0.95和0.8 ng cm-3。这种简单快速的方法具有良好的精密度和准确度。基于精确质量测量提出了衍生化MMA和DMA的裂解途径。
