Theiler Martin, Kempf Werner, Kerl Katrin, French Lars E, Hofbauer Günther Fl
Department of Dermatology, University Hospital, Zurich, Switzerland.
J Dermatol Case Rep. 2011 Jun 6;5(2):19-23. doi: 10.3315/jdcr.2011.1066.
Molluscum contagiosum (MC) is a frequent and usually benign cutaneous infection with molluscum contagiosum virus (MCV), affecting mainly children and young sexually active adults. With the emergence of HIV/AIDS, a new patient group at risk has been identified with often extensive skin involvement and recalcitrant disease.
We report a case of a girl with connatal HIV-infection, suffering from extensive, disseminated MC. Due to multi-resistance, an effective antiretroviral therapy could not be established for years, rendering an effective treatment of MC by established treatment options virtually impossible. An off-label use of imiquimod showed a marked improvement of lesion counts in this patient, whereas a complete clearance could only be achieved once effective antiretroviral therapy was introduced.
We believe that imiquimod may represent a valuable treatment option for molluscum contagiosum especially in the context of marked immunosuppression, where sensitive areas like the face and neck are often involved and scarring must be avoided.
传染性软疣（MC）是由传染性软疣病毒（MCV）引起的一种常见且通常为良性的皮肤感染，主要影响儿童和性活跃的年轻成年人。随着艾滋病毒/艾滋病的出现，已确定了一个新的高危患者群体，他们常常有广泛的皮肤受累且病情顽固。
我们报告了一例先天性艾滋病毒感染的女孩，患有广泛播散性传染性软疣。由于多重耐药，多年来无法建立有效的抗逆转录病毒治疗，因此几乎不可能通过既定的治疗方案有效治疗传染性软疣。咪喹莫特的非标签使用使该患者的皮损数量显著改善，而只有在引入有效的抗逆转录病毒治疗后才实现了完全清除。
我们认为，咪喹莫特可能是治疗传染性软疣的一种有价值的选择，特别是在明显免疫抑制的情况下，此时面部和颈部等敏感部位常受累且必须避免瘢痕形成。
