Gerke D C, Frewin D B, Frost B R
Aust J Exp Biol Med Sci. 1976 Oct;54(5):467-74. doi: 10.1038/icb.1976.47.
The blood vessels in the rabbit ear have been used to investigate the effects of octapressin on vascular smooth muscle. Continuous administration of this drug resulted in tachphlatis. Cocaine enhanced the response of the ear to octapressin; however, this potentiation was not evident when phentolamine was concurrently added to the perfusate. Denervation and reserpinisation of the ear also eliminated the potentiation of octapressin's response by cocaine. The results suggest that there is a small, indirect sympathomimetic component involved in octapressin's action on the vasculature.
兔耳血管已被用于研究八肽加压素对血管平滑肌的作用。持续给予这种药物会导致血管收缩。可卡因增强了兔耳对八肽加压素的反应；然而，当酚妥拉明同时加入灌注液时，这种增强作用并不明显。兔耳去神经支配和利血平化也消除了可卡因对八肽加压素反应的增强作用。结果表明，八肽加压素对血管系统的作用涉及一个小的、间接的拟交感神经成分。
