Valmaggia C, Speiser P, Bischoff P, Niederberger H
Department of Ophthalmology, Kantonsspital St. Gallen, Switzerland.
Retina. 1999;19(2):131-4. doi: 10.1097/00006982-199902000-00008.
We evaluated in a prospective study the usefulness of indocyanine green (ICG) versus fluorescein angiography in the differential diagnosis between arteritic and nonarteritic anterior ischemic optic neuropathy (AION).
Simultaneous ICG and fluorescein angiography was performed on 22 eyes with AION. Appearance of both dyes in the choroid and in the retina, laminar flow, venous filling, and complete filling of the choroid were measured independently. Massive delayed choroidal filling corresponding to occluded posterior ciliary arteries was especially assessed, as it is almost always diagnostic of arteritic AION. We considered the choroidal filling as massive delayed if it was still incomplete after the venous filling.
We diagnosed 5 arteritic AIONs, confirmed by biopsy, and 17 nonarteritic AIONs. In both types of angiography, 3 of 5 patients with arteritic AION showed massive delayed complete choroidal filling times (44.2, 45.8, and 70 seconds), and patients with nonarteritic AION had normal complete choroidal filling times. Dye appearance at the different angiographic times was similar for fluorescein and ICG angiography (P = 0.95-0.96).
Fluorescein angiography alone is sufficient to reveal massive delayed choroidal filling time in arteritic AION. For our purpose, ICG angiography provides no additional information.
我们在一项前瞻性研究中评估了吲哚菁绿（ICG）与荧光素血管造影术在动脉炎性和非动脉炎性前部缺血性视神经病变（AION）鉴别诊断中的作用。
对22例AION患者的眼睛同时进行ICG和荧光素血管造影。分别测量两种染料在脉络膜和视网膜中的表现、层流、静脉充盈以及脉络膜的完全充盈情况。特别评估了与睫状后动脉阻塞相对应的大量延迟脉络膜充盈，因为它几乎总是动脉炎性AION的诊断依据。如果在静脉充盈后脉络膜充盈仍不完全，我们则认为脉络膜充盈为大量延迟。
我们诊断出5例经活检证实的动脉炎性AION和17例非动脉炎性AION。在两种血管造影类型中，5例动脉炎性AION患者中有3例显示出大量延迟的完全脉络膜充盈时间（44.2、45.8和70秒），而非动脉炎性AION患者的脉络膜完全充盈时间正常。荧光素血管造影和ICG血管造影在不同血管造影时间的染料表现相似（P = 0.95 - 0.96）。
仅荧光素血管造影就足以显示动脉炎性AION中大量延迟的脉络膜充盈时间。就我们的目的而言，ICG血管造影没有提供额外信息。
