Aukema H M, Housini I, Rawling J M
Department of Nutrition and Food Sciences, and Center for Research on Women's Health, Texas Woman's University, Denton 76204-5888, USA.
J Am Soc Nephrol. 1999 Feb;10(2):300-8. doi: 10.1681/ASN.V102300.
The effects of dietary soy protein compared to casein were examined in male and female CD1-pcy/pcy (pcy) mice with polycystic kidney disease. Animals 10 wk of age were fed purified diets containing either soy protein isolate or casein given at a level of 17.4 or 6% protein. After 13 wk on the diets, body weights and serum concentrations of albumin and protein indicated that protein nutrition was adequate on all diets. Overall, animals fed soy protein versus casein had 28% lower (P = 0.0037) relative kidney weights (g/100 g body wt), 37% lower (P = 0.0089) cyst scores (% cyst area x relative kidney weight), and 25% less (P = 0.0144) kidney water (g). Dietary protein reduction resulted in 30% lower (P = 0.0010) relative kidney weights, 25% lower (P = 0.0327) cyst scores, and 35% less (P = 0.0001) kidney water. Analysis of interactions between main effects revealed that the effects of soy protein on kidney size were significant only in females, and that effects of soy protein on cyst score were significant only in animals on the low protein diets. In addition, differences in kidney weights and cyst score due to protein reduction were significant in animals fed soy protein, but not in those fed casein as the protein source. These results show that both dietary protein source and level significantly affect polycystic kidney disease in pcy animals, with the effects of dietary soy protein being most pronounced in female animals fed the low protein diets and the effects of protein reduction being most pronounced in animals fed soy protein-based diets.
在患有多囊肾病的雄性和雌性CD1-pcy/pcy（pcy）小鼠中，研究了膳食大豆蛋白与酪蛋白相比的效果。给10周龄的动物喂食纯化日粮，其中含有大豆分离蛋白或酪蛋白，蛋白质水平分别为17.4%或6%。在日粮喂养13周后，体重以及血清白蛋白和蛋白质浓度表明所有日粮的蛋白质营养均充足。总体而言，与喂食酪蛋白的动物相比，喂食大豆蛋白的动物相对肾脏重量（克/100克体重）低28%（P = 0.0037），囊肿评分（囊肿面积百分比×相对肾脏重量）低37%（P = 0.0089），肾脏含水量少25%（P = 0.0144）。减少膳食蛋白质导致相对肾脏重量降低30%（P = 0.0010），囊肿评分降低25%（P = 0.0327），肾脏含水量减少35%（P = 0.0001）。对主要效应之间相互作用的分析表明，大豆蛋白对肾脏大小的影响仅在雌性中显著，大豆蛋白对囊肿评分的影响仅在低蛋白日粮的动物中显著。此外，蛋白质减少导致的肾脏重量和囊肿评分差异在喂食大豆蛋白的动物中显著，但在以酪蛋白为蛋白质来源的动物中不显著。这些结果表明膳食蛋白质来源和水平均显著影响pcy动物的多囊肾病，膳食大豆蛋白的影响在喂食低蛋白日粮的雌性动物中最为明显，而蛋白质减少的影响在喂食大豆蛋白日粮的动物中最为明显。
