血管生成素-3，血管生成素家族的一个新成员。

Angiopoietin-3, a novel member of the angiopoietin family.

作者信息

Nishimura M, Miki T, Yashima R, Yokoi N, Yano H, Sato Y, Seino S

机构信息

The Program of the Chiba University School of Medicine, Chiba University Graduate School of Medicine, Japan.

出版信息

FEBS Lett. 1999 Apr 9;448(2-3):254-6. doi: 10.1016/s0014-5793(99)00381-6.

DOI:10.1016/s0014-5793(99)00381-6

PMID:10218486

Abstract

A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.

摘要

一个编码血管生成素-3蛋白（Ang3）（血管生成素家族的一个新成员）的cDNA克隆被鉴定出来。Ang3 cDNA是从人主动脉cDNA文库中克隆得到的。Ang3是一种由503个氨基酸组成的蛋白质，与人血管生成素-1和人血管生成素-2的同源性分别为45.1%和44.7%。Ang3 mRNA在肺和培养的人脐静脉内皮细胞（HUVECs）中表达。血管内皮细胞生长因子处理后，HUVECs中Ang3 mRNA的表达略有下降，这表明Ang3 mRNA表达的调控与Ang2不同。