Bobyn J D, Toh K K, Hacking S A, Tanzer M, Krygier J J
Division of Orthopaedics, Montreal General Hospital, McGill University, Quebec, Canada.
J Arthroplasty. 1999 Apr;14(3):347-54. doi: 10.1016/s0883-5403(99)90062-1.
This study evaluated the osseous tissue response to a noncemented metal-backed acetabular component made of a new porous tantalum biomaterial. Eleven dogs with bilateral total hip arthroplasties (22 acetabular implants) were studied for a period of 6 months. Thin section histology, high-resolution radiography, and backscattered scanning electron microscopy revealed that all 22 implants had stable bone-implant interfaces. Regions of bone ingrowth were present in all histologic sections. The depth of bone ingrowth varied from 0.2 mm to the maximal limit of 2 mm. Analyzing contiguous regions of interest across the full bone-implant interface, the mean bone ingrowth for all sections was 16.8% +/- 5.7%. In the peripheral regions of the cup where bone-implant contact was most consistent, bone ingrowth averaged 25.1% +/- 10.1%. The data indicate that the porous tantalum material is effective for biologic fixation in the dog and may provide a suitable alternative to other porous materials used in acetabular cup design.
本研究评估了一种由新型多孔钽生物材料制成的非骨水泥金属背衬髋臼部件的骨组织反应。对11只接受双侧全髋关节置换术的犬（22个髋臼植入物）进行了为期6个月的研究。薄切片组织学、高分辨率放射摄影和背散射扫描电子显微镜检查显示，所有22个植入物均具有稳定的骨-植入物界面。所有组织学切片中均存在骨长入区域。骨长入深度从0.2毫米到最大2毫米不等。分析整个骨-植入物界面的相邻感兴趣区域，所有切片的平均骨长入率为16.8%±5.7%。在髋臼杯的周边区域，骨与植入物的接触最为一致，骨长入平均为25.1%±10.1%。数据表明，多孔钽材料在犬体内对生物固定有效，可能为髋臼杯设计中使用的其他多孔材料提供合适的替代方案。
