Bondarenko Stanislav, Dedukh Ninel, Filipenko Volodymyr, Akonjom Mandus, Badnaoui Ahmed Amine, Schwarzkopf Ran
1 Sytenko Institute of Spine and Joint Pathology National Academy of Medical Science of Ukraine, Kharkiv, Ukraine.
2 NYU Langone Medical Center, Hospital for Joint Diseases, New York, NY.
Hip Int. 2018 Nov;28(6):622-628. doi: 10.1177/1120700018759314. Epub 2018 May 9.
There is a lack of comparative data on osseointegration (BIC) of acetabular cup surfaces in hip arthroplasty in both normal bone mineral density and in conditions of osteoporosis.
To compare osseointegration of acetabular implants with various types of surfaces in an animal model with normal and osteoporotic bone tissue.
The study was performed on 60 rats. To simulate osteoporosis ovariectomy was performed in 30 animals. Thirty healthy rats served as controls. In standardised defects of the distal metadiaphysis of the femur we implanted: porous tantalum Trabecular Metal (A), Trabecular Titanium (B), Titanium with Gription coating (C), Stiktite (D), and Tritanum (E). Bone apposition (osseointegration) was defined as all areas of direct "bone-to-implant contact" (BIC).
No qualitative morphological differences in the evaluation of BIC around different implant types was seen in normal rats and rats with osteoporosis. Connective tissue areas around implants were larger in rats with osteoporosis. Morphometric studies showed that the highest BIC were seen in implants A and B, both in healthy animals ([72.00 ± 3.48]% and [67.46 ± 1.69]%) and ones with osteoporosis ([59.19 ± 2.10]% and [53.36 ± 2.57]%). BIC was (60.10 ± 2.05)%, (60.26 ± 2.36)%, and (61.78 ± 2.27)% around implants C, D and E in healthy rats, respectively. BIC in osteoporosis was (45.39 ± 2.37)%, (47.81 ± 2.41)% and (42.10 ± 1.44)%, respectively.
Our study showed that the evaluated implants have good BIC features. Furthermore, based on histomorthometry and histology, Porous tantalum Trabecular Metal (A) and Trabecular Titanium (B) implants exhibit higher BIC with bone tissue.
在正常骨密度以及骨质疏松情况下，髋关节置换术中髋臼杯表面骨整合（骨-植入物接触率，BIC）的比较数据尚缺。
在具有正常和骨质疏松骨组织的动物模型中，比较不同类型表面的髋臼植入物的骨整合情况。
对60只大鼠进行研究。通过对30只动物实施卵巢切除术来模拟骨质疏松。30只健康大鼠作为对照。在股骨远端干骺端的标准化缺损处植入：多孔钽小梁金属（A）、小梁钛（B）、带Gription涂层的钛（C）、Stiktite（D）和Tritanum（E）。骨附着（骨整合）定义为直接“骨-植入物接触”（BIC）的所有区域。
在正常大鼠和骨质疏松大鼠中，不同植入物类型周围BIC评估未见定性形态学差异。骨质疏松大鼠植入物周围的结缔组织面积更大。形态计量学研究表明，植入物A和B的BIC最高，在健康动物中分别为（72.00±3.48）%和（67.46±1.69）%，在骨质疏松动物中分别为（59.19±2.10）%和（53.36±2.57）%。健康大鼠中植入物C、D和E周围的BIC分别为（60.10±2.05）%、（60.26±2.36）%和（61.78±2.27）%。骨质疏松时的BIC分别为（45.39±2.37）%、（47.81±2.41）%和（42.10±1.44）%。
我们的研究表明，所评估的植入物具有良好的BIC特征。此外，基于组织形态计量学和组织学，多孔钽小梁金属（A）和小梁钛（B）植入物与骨组织的BIC更高。
