Zhang Z Q, Schuler T, Cavert W, Notermans D W, Gebhard K, Henry K, Havlir D V, Günthard H F, Wong J K, Little S, Feinberg M B, Polis M A, Schrager L K, Schacker T W, Richman D D, Corey L, Danner S A, Haase A T
Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5169-72. doi: 10.1073/pnas.96.9.5169.
Over the course of HIV-1 infection, the lymphoid follicles where the humoral immune response is generated initially increase in size and number and then progressively involute. In advanced disease, the network of the processes of follicular dendritic cells (FDCs) that serve as antigen repositories and anatomical substrate for B and T cells and antigen to interact is destroyed, contributing to the breakdown of the immune system. Because destruction of FDCs is associated with deposition of HIV-1, and much of the virus can be cleared from the network with antiretroviral therapy, we investigated the reversibility of damage. We measured the immunohistochemically stainable FDC compartment by quantitative image analysis, and we documented changes in this compartment at different stages of disease. We show that treatment, initiated even at advanced stages of HIV-1 disease, can slowly reverse pathological changes in the FDC network.
在HIV-1感染过程中，最初产生体液免疫反应的淋巴滤泡大小和数量会增加，随后逐渐退化。在疾病晚期，作为B细胞、T细胞和抗原相互作用的抗原储存库及解剖学基质的滤泡树突状细胞（FDC）的突起网络遭到破坏，这促使免疫系统崩溃。由于FDC的破坏与HIV-1的沉积有关，并且通过抗逆转录病毒疗法可以从该网络中清除大部分病毒，因此我们研究了损伤的可逆性。我们通过定量图像分析测量了免疫组化可染色的FDC区室，并记录了疾病不同阶段该区域的变化。我们发现，即使在HIV-1疾病的晚期开始治疗，也能缓慢逆转FDC网络中的病理变化。
