Nowak M, Oszukowski P, Szpakowski M, Małafiej E, Malinowski A, Wieczorek A, Wierzbicka E, Drzazga W
Instytutu Centrum Zdrowia Matki Polki.
Ginekol Pol. 1998 Dec;69(12):1283-7.
The purpose of our study was to determine maternal serum concentrations of IL-8, IL-6, IFN-gamma during normal pregnancy and labor.
Maternal serum IL-8, IL-6 and IFN-gamma levels were measured by means of ELISA technique in 41 healthy pregnant women in 22-42 week gestation and 15 healthy women in labor at term. All newborns and afterbirths had no signs of infection.
IL-8 values for pregnant women ranged from 1.98 to 35.2 pg/ml with the median value 10.24 pg/ml, and the 95th percentile 24.5 pg/ml. IL-8 values for women in labor at term ranged from 3.96 to 54.8 pg/ml with the median 10.4 pg/ml. No statistically significant changes in serum IL-8 concentration were observed during pregnancy or in labor. Serum IL-6 concentrations in pregnant women ranged from 0 to 21.7 pg/ml with the median value 0 pg/ml, and the 95th percentile 15.5 pg/ml. Serum IL-6 concentrations in women in labor at term were significantly higher (p < 0.05): ranged from 0 to 39.2 pg/ml with the median 10.1 pg/ml and 95-th percentile 33.5 pg/ml. Maternal serum IFN-gamma concentrations in pregnant women ranged from 0 to 9.8 pg/ml with the median value 3.9 pg/ml, the 95th percentile 9.2 pg/ml and didn't differ during labor at term: range from 0 to 14.5 pg/ml, median 1.9 pg/ml.
Our data revealed that maternal serum IL-8 concentrations didn't changed during the course of pregnancy and in labor. Women in labor had significantly elevated serum IL-6 concentrations compared to those in pregnancy. We didn't observed such changes in serum IFN-gamma levels.
本研究的目的是测定正常妊娠和分娩期间母体血清中白细胞介素-8（IL-8）、白细胞介素-6（IL-6）、γ-干扰素（IFN-γ）的浓度。
采用酶联免疫吸附测定（ELISA）技术，对41例妊娠22 - 42周的健康孕妇和15例足月分娩的健康妇女测定母体血清IL-8、IL-6和IFN-γ水平。所有新生儿和胎盘均无感染迹象。
孕妇的IL-8值范围为1.98至35.2 pg/ml，中位数为10.24 pg/ml，第95百分位数为24.5 pg/ml。足月分娩妇女的IL-8值范围为3.96至54.8 pg/ml，中位数为10.4 pg/ml。在妊娠期间或分娩过程中，未观察到血清IL-8浓度有统计学显著变化。孕妇血清IL-6浓度范围为0至21.7 pg/ml，中位数为0 pg/ml，第95百分位数为15.5 pg/ml。足月分娩妇女的血清IL-6浓度显著更高（p < 0.05）：范围为0至39.2 pg/ml，中位数为10.1 pg/ml，第95百分位数为33.5 pg/ml。孕妇母体血清IFN-γ浓度范围为0至9.8 pg/ml，中位数为3.9 pg/ml，第95百分位数为9.2 pg/ml，足月分娩时无差异：范围为0至14.5 pg/ml，中位数为1.9 pg/ml。
我们的数据显示，母体血清IL-8浓度在妊娠过程和分娩期间没有变化。与妊娠妇女相比，分娩妇女的血清IL-6浓度显著升高。我们未观察到血清IFN-γ水平有此类变化。
