Mastrocola C, Vanacore N, Giovani A, Locuratolo N, Vella C, Alessandri A, Baratta L, Tubani L, Meco G
Department of Clinical Medicine, University of La Sapienza, Rome, Italy.
Acta Neurol Scand. 1999 Apr;99(4):245-7. doi: 10.1111/j.1600-0404.1999.tb07355.x.
To evaluate the autonomic dysfunction in Parkinson's disease patients by means of a 24-h heart rate variability (HRV) method.
Thirteen patients with a diagnosis of Parkinson's disease were compared with 13 age-matched healthy persons (control group). The 13 patients had a mean age of 70.5 years, and mean disease duration of 10.9 years. The autonomic function was evaluated by HRV analysis using a continuous 24-h ECG. The parameters of SDNN (standard deviation of the normal-to-normal intervals between adjacent QRS complexes), of LF (power in low frequency) and of HF (power in high frequency) were studied during the following 3 periods: 24 h, night and day.
The data show a statistically significant difference between groups for SDNN and LF in all the periods, while for HF parameters the difference is statistically significant only in the night period.
The use of the 24-h HRV method can provide more accurate and reproducible data than other conventional cardiovascular tests.
通过24小时心率变异性（HRV）方法评估帕金森病患者的自主神经功能障碍。
将13例诊断为帕金森病的患者与13例年龄匹配的健康人（对照组）进行比较。13例患者的平均年龄为70.5岁，平均病程为10.9年。使用连续24小时心电图通过HRV分析评估自主神经功能。在以下3个时间段研究了SDNN（相邻QRS波群之间正常到正常间期的标准差）、LF（低频功率）和HF（高频功率）参数：24小时、夜间和白天。
数据显示，在所有时间段，两组之间SDNN和LF存在统计学显著差异，而对于HF参数，仅在夜间差异具有统计学显著性。
与其他传统心血管检查相比，使用24小时HRV方法可以提供更准确和可重复的数据。
