Singh G, Triadafilopoulos G
Department of Medicine, Division of Immunology, Stanford University School of Medicine, Palo Alto, California 94304, USA.
J Rheumatol Suppl. 1999 Apr;56:18-24.
Nonsteroidal antiinflammatory drugs (NSAID) are one of the most commonly used classes of medications worldwide. It is estimated that more than 30 million people take NSAID daily. Gastrointestinal (GI) complications related to NSAID therapy are the most prevalent category of adverse drug reactions. Patients with arthritis are among the most frequent users of NSAID and are therefore particularly at risk for these side effects. To evaluate the nature of NSAID-related GI complications and to determine how their frequency can be reduced, a series of studies of such complications in patients with rheumatic disease have been carried out based on data from the Arthritis, Rheumatism, and Aging Medical Information System (ARAMIS). This report briefly reviews the literature and presents recent findings from the ARAMIS studies, which provide an update on published information. It addresses whether GI side effects such as dyspepsia can serve as warning symptoms for life-threatening GI complications and describes the risk factors for these events. It also summarizes a study that investigated whether H2-receptor antagonists and antacids affect the development of serious GI complications. In addition, ongoing research and topics to be addressed in future studies are described.
非甾体抗炎药（NSAID）是全球最常用的药物类别之一。据估计，每天有超过3000万人服用NSAID。与NSAID治疗相关的胃肠道（GI）并发症是最常见的药物不良反应类型。关节炎患者是NSAID最频繁的使用者之一，因此特别容易出现这些副作用。为了评估与NSAID相关的GI并发症的性质，并确定如何降低其发生率，基于关节炎、风湿病和衰老医学信息系统（ARAMIS）的数据，对风湿病患者的此类并发症进行了一系列研究。本报告简要回顾了文献，并介绍了ARAMIS研究的最新发现，这些发现提供了已发表信息的更新。它探讨了诸如消化不良等GI副作用是否可作为危及生命的GI并发症的警示症状，并描述了这些事件的风险因素。它还总结了一项研究，该研究调查了H2受体拮抗剂和抗酸剂是否会影响严重GI并发症的发生。此外，还描述了正在进行的研究以及未来研究中要解决的主题。
