1型人类免疫缺陷病毒感染患者肺炎球菌免疫后血浆中促炎细胞因子水平。
Levels of proinflammatory cytokines in plasma after pneumoccoccal immunization in human immunodeficiency virus type 1-infected patients.
作者信息
Valdez H, Purvis S, Asaad R, Valerio I, Sha B E, Landay A L, Lederman M M
机构信息
Case Western Reserve University Center for AIDS Research and University Hospitals of Cleveland, Cleveland, Ohio 44106-5083, USA.
出版信息
Clin Diagn Lab Immunol. 1999 May;6(3):427-8. doi: 10.1128/CDLI.6.3.427-428.1999.
Abstract
To ascertain if immunization with pneumococcal polysaccharide vaccine is associated with rises in the levels of proinflammatory cytokines in the plasma of human immunodeficiency virus type 1 (HIV-1)-infected patients, the levels of tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) were measured serially after immunization. IL-6 levels rose an average of 2.2- and 2.1-fold 6 and 8 h after immunization, respectively, but TNF-alpha levels remained unchanged. The levels of these cytokines were stable in unimmunized controls. Immunization with pneumococcal polysaccharide vaccine induces increases in the levels of IL-6 in the plasma of persons with HIV-1 infection.
摘要
为了确定肺炎球菌多糖疫苗免疫接种是否与1型人类免疫缺陷病毒（HIV-1）感染患者血浆中促炎细胞因子水平升高有关，在免疫接种后连续测量肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）的水平。免疫接种后6小时和8小时，IL-6水平分别平均升高2.2倍和2.1倍，但TNF-α水平保持不变。在未免疫的对照中，这些细胞因子的水平是稳定的。肺炎球菌多糖疫苗免疫接种可导致HIV-1感染人群血浆中IL-6水平升高。
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