Balakrishnan S
Lepr India. 1976 Oct;48(4):406-12.
Sequential biochemical investigations conducted in cases of lepromatous leprosy in the reactive as well as subsided phases indicated elevated serum levels of mucoproteins and sialic acids and skin levels of hydroxy-proline and hexosamine in the reactive phase of lepromatous leprosy. Elevation of the urinary excretion of hydroxy-proline and certain other amino acids was also noticed during 'lepra reaction'. Enhancement of serum levels of Aldolase, CPK, LDH and transaminases was observed in the reactive phase of lepromatous leprosy. These findings taken as a whole suggest a generalised tissue breakdown in lepra reaction.
在瘤型麻风反应期及消退期对瘤型麻风患者进行的系列生化检查表明，瘤型麻风反应期血清粘蛋白和唾液酸水平升高，皮肤羟脯氨酸和己糖胺水平升高。在“麻风反应”期间还注意到尿羟脯氨酸和某些其他氨基酸排泄增加。在瘤型麻风反应期观察到醛缩酶、肌酸磷酸激酶、乳酸脱氢酶和转氨酶的血清水平升高。总体而言，这些发现提示麻风反应中存在全身性组织破坏。
