Crick F H, Brenner S, Klug A, Pieczenik G
Orig Life. 1976 Dec;7(4):389-97. doi: 10.1007/BF00927934.
It is suggested that protein sythesis may have begun without even a primitive ribosome if the primitive tRNA could take up two configuration and could bind to the messenger RNA with five base-pairs instead of the present three. This idea would impose base sequence restriction on the early messages and on the early genetic code such that the first four amino acids coded were glycine, serine, aspartic acid and aspargine. A possible mechanism is suggested for the polymerization of the early message.
有人提出，如果原始转运RNA能够呈现两种构象，并且能以五个碱基对而非目前的三个碱基对与信使RNA结合，那么蛋白质合成甚至可能在没有原始核糖体的情况下就已开始。这一观点会对早期的信使RNA和早期遗传密码施加碱基序列限制，使得最初编码的四个氨基酸是甘氨酸、丝氨酸、天冬氨酸和天冬酰胺。文中还提出了一种早期信使RNA聚合的可能机制。
