Rao V K, Krasan G P, Hendrixson D R, Dawid S, St Geme J W
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
FEMS Microbiol Rev. 1999 Apr;23(2):99-129. doi: 10.1111/j.1574-6976.1999.tb00393.x.
Non-typable Haemophilus influenzae is a common commensal organism in the human upper respiratory tract and an important cause of localized respiratory tract disease. The pathogenesis of disease begins with bacterial colonization of the nasopharynx, a process that involves establishment on the mucosal surface and evasion of local immune mechanisms. Under the proper circumstances, the organism spreads contiguously to the middle ear, the sinuses, or the lungs, and then stimulates a brisk inflammatory response, producing symptomatic infection. In this review, we summarize our present understanding of the molecular determinants of this sequence of events. Continued investigation of the molecular mechanism of non-typable H. influenzae pathogenicity should facilitate development of novel approaches to the treatment and prevention of H. influenzae disease.
不可分型流感嗜血杆菌是人类上呼吸道常见的共生菌，也是局部呼吸道疾病的重要病因。疾病的发病机制始于鼻咽部的细菌定植，这一过程涉及在黏膜表面的定植以及逃避局部免疫机制。在适当情况下，该菌会连续扩散至中耳、鼻窦或肺部，进而引发强烈的炎症反应，导致出现症状性感染。在本综述中，我们总结了目前对这一系列事件分子决定因素的认识。对不可分型流感嗜血杆菌致病性分子机制的持续研究应有助于开发治疗和预防流感嗜血杆菌疾病的新方法。
