Velegraki A, Nicolatou O, Theodoridou M, Mostrou G, Legakis N J
Department of Microbiology, Medical School, University of Athens, Greece.
J Oral Pathol Med. 1999 Apr;28(4):178-82. doi: 10.1111/j.1600-0714.1999.tb02020.x.
Three vertically HIV-infected children showed, in addition to oral candidiasis, HIV-gingivitis, which healed on antimycotic treatment. The intense linear gingival erythema of a fourth child was also clinically evaluated as a possible form of erythematous oral candidiasis. Direct microscopic examination of material from the gingival lesions of the latter disclosed yeast cells and hyphae. Subsequent culture, biochemical and serological tests identified the yeast as Candida dubliniensis. As the patient was on long-term prophylaxis with fluconazole, ketoconazole was administered and led to a good clinical response. This is the first report implicating this new Candida species as a pathogen in linear gingival erythema in a HIV-positive individual. The case reports presented provide evidence that linear gingival erythema may be of candidal origin. Further clinical and laboratory observations are required to establish whether this condition constitutes a variant of erythematous candidiasis associated with paediatric HIV infection.
三名垂直感染艾滋病毒的儿童，除了患有口腔念珠菌病外，还患有艾滋病毒牙龈炎，经抗真菌治疗后痊愈。第四名儿童的严重线性牙龈红斑在临床上也被评估为红斑型口腔念珠菌病的一种可能形式。对后者牙龈病变材料的直接显微镜检查发现了酵母细胞和菌丝。随后的培养、生化和血清学检测确定该酵母为都柏林念珠菌。由于该患者长期接受氟康唑预防治疗，遂给予酮康唑治疗，临床反应良好。这是首例将这种新的念珠菌属作为艾滋病毒阳性个体线性牙龈红斑病原体的报告。所呈现的病例报告提供了证据，表明线性牙龈红斑可能源于念珠菌。需要进一步的临床和实验室观察，以确定这种情况是否构成与儿童艾滋病毒感染相关的红斑型念珠菌病的一种变体。
