Bolotovskiĭ V M, Beliakova L O, Titova N S
Zh Mikrobiol Epidemiol Immunobiol. 1976(12):108-12.
The work was carried out under conditions of mass measles immunization at the polyclincs of Moscow and Dushanbe. The role of the macroorganism at the time of vaccination on the measles vaccination process was investigated. A thorough study of the anamnesis, its allergic predisposition was conducted; blood and C-RB were examined, and the content of serum immunoglobulins was determined by Macini's method. The results obtained pointed to the insufficiently complete detection of children with an altered reactivity by a simple examination by the physician alone. It was revealed that children suffering from various forms of allergy having in the anamnesis hypotrophy rickets and frequent acute respiratory diseases and chronic foci of infections had decreased indice of nonsecific immunological reactivity even at the period of clinical well-being, and could be detected only by means of laboratory methods of study. To the administration of measles vaccine such children responded not only by the development of clinical reactions of different intensity, but also by a significant reduction of antibody formation. All the aforesaid indicates a necessity of further study of the mechanism of establishment of postvaccinal measles immunity with consideration to the individual reactivity of the child organism.
这项工作是在莫斯科和杜尚别的多科联合诊所大规模麻疹免疫接种的条件下开展的。研究了机体在接种麻疹疫苗时对麻疹疫苗接种过程的作用。对病史进行了全面研究，调查了其过敏倾向；检查了血液和C - RB，并采用马奇尼方法测定了血清免疫球蛋白含量。所得结果表明，仅靠医生简单检查，对反应性改变的儿童检测不够全面。结果显示，患有各种形式过敏、有发育迟缓、佝偻病病史以及频繁患急性呼吸道疾病和慢性感染病灶的儿童，即使在临床康复期非特异性免疫反应指标也会降低，而且只能通过实验室研究方法检测出来。对于这些儿童接种麻疹疫苗，不仅会引发不同强度的临床反应，而且抗体形成也会显著减少。上述所有情况表明，有必要进一步研究在考虑儿童机体个体反应性的情况下建立疫苗接种后麻疹免疫力的机制。
