Tikhonova N T, Khrometskaia T M, Livanova L V, Poliakova T A, Azarova S A
Vopr Virusol. 1978 May-Jun(3):322-7.
The dynamics of the total content of measles antibody with reference to their physico-chemical nature and the dynamics of the content of the main classes of serum immunoglobulins (A, M, G) in children previously vaccinated and not vaccinated with live measles vaccine who developed measles were studied. Measles in the vaccines was found to run a course of the type of primary and secondary infection. In the former case, the normal dynamics of specific antibody was found with timely change of synthesis of antibody of various physico-chemical nature. In the latter case, immunity to measles developed according to the secondary type and was characterized by the absence of IgM measles antibody. The secondary immunological response was also characterized by higher antibody titers in the first days of the disease and decreased content of IgG and IgM in sera in the convalescent stage. Besides, in such children, hyperthermia occurred 3 times less frequently.
研究了患麻疹的曾接种和未接种过麻疹活疫苗儿童的麻疹抗体总含量的动态变化及其物理化学性质，以及血清免疫球蛋白主要类别（A、M、G）含量的动态变化。发现疫苗接种后麻疹呈原发性和继发性感染类型。在前一种情况下，发现特异性抗体的正常动态变化以及不同物理化学性质抗体合成的及时变化。在后一种情况下，麻疹免疫力呈继发性发展，其特征是没有麻疹IgM抗体。继发性免疫反应还表现为疾病初期抗体滴度较高，恢复期血清中IgG和IgM含量降低。此外，这类儿童高热发生频率降低3倍。
